Journal: ChemMedChem
Article Title: Hybrid BisQACs: Potent Biscationic Quaternary Ammonium Compounds Merging the Structures of Two Commercial Antiseptics
doi: 10.1002/cmdc.201700597
Figure Lengend Snippet: Antimicrobial activity (MIC) and red blood cell lysis data for amphiphiles; Gram-negative bacteria ( E. coli and P. aeruginosa ) are highlighted in red. [a]
Article Snippet: [ 8 , 11 ] The complete set of MIC values against six bacteria [ Staphylococcus aureus , Enterococcus faecalis , Escherichia coli , Pseudomonas aeruginosa , community-acquired methicillin-resistant SA (USA300-0114), hospital-acquired methicillin-resistant SA (ATCC 33591)], along with red blood cell lysis (presented as lysis 20 , the highest concentration at which <20 % of RBCs are lysed), is presented in . table ft1 table-wrap mode="anchored" t5 caption a7 Series Compound Minimum Inhibitory Concentration (MIC) [μM] Lysis 20 [μM] S. aureus E. faecalis E. coli P. aeruginosa USA300-0114 ATCC 33591 BAC 8 8 32 63 32 16 63 CPC 0.5 1 8 63 16 1 8 m- Hy- n ,0 m- Hy-10,0 32 >250 125 250 32 63 NT m- Hy-12,0 63 250 125 250 63 125 NT m- Hy-14,0 8 250 32 >250 8 32 63 m- Hy-16,0 2 125 16 250 2 4 16 Hybrid BisQACs m- Hy- n , n m- Hy-8,8 63 >250 >250 250 32 250 NT m- Hy-10,10 2 32 4 16 1 4 32 m- Hy-11,11 2 4 2 4 1 2 16 m- Hy-12,12 2 4 1 4 1 2 8 m- Hy-13,13 2 32 2 16 2 2 8 m- Hy-14,14 2 63 4 63 2 4 8 m- Hy-16,16 2 250 63 250 2 4 16 m- Hy-18,18 8 >250 125 >250 16 8 63 Asymmetric Hybrid BisQACS m- Hy- n , n A m- Hy-10,11A 2 8 2 8 1 2 32 m- Hy-10,12A 2 16 4 8 2 4 32 m- Hy-10,13A 2 4 2 4 2 2 16 m- Hy-12,11A 2 4 2 4 2 2 16 m- Hy-12,12A 2 4 2 8 2 2 8 m- Hy-12,13A 4 4 2 4 2 2 16 m- Hy-10,15A 2 8 2 8 2 4 16 m- Hy-14,11A 2 8 2 16 4 2 16 m- Hy-14,12A 2 16 2 32 2 4 16 m- Hy-14,13A 4 32 4 63 4 4 8 m- Hy-16,11A 4 16 4 32 2 4 8 m- Hy-12,15A 4 8 4 8 4 4 16 m- Hy-16,12A 4 63 4 63 4 4 16 m- Hy-14,15A 8 63 8 125 8 8 16 m- Hy-16,13A 4 63 16 125 8 4 16 m- Hy-16,15A 16 >250 63 >250 16 16 32 Open in a separate window [a] NT =not tested.
Techniques: Activity Assay, Red Blood Cell Lysis, Bacteria, Concentration Assay, Lysis